When Boss Baby and Tim are looking for the plans, Boss Baby throws his disguise into the bin. The way it lands in the bin directly mirrors The Spider-Man story 'Spider-Man no More'. Tobey Maguire, who voices the older Tim portrayed Peter Parker / Spider-Man for three movies, the second of which - Spider-Man 2 (2004) - also pays homage to this iconic image.
When the babies are caught having a meeting and they resume acting like babies, the music heard is the first few bars of the theme song from The Banana Splits Adventure Hour (1968), a popular kids Saturday morning show in the 1960's, whose main characters (actors in life-sized animal costumes) were inspired by The Monkees (1966).
While Tim describes his parents' exciting jobs in marketing, a shot of them "launching" new products shows them simultaneously turning launch keys in an allusion to the opening sequence of WarGames (1983).
The Boss Baby, voiced by Alec Baldwin, speaks of writing the best memo of his career. Baldwin's character Jack Ryan in À la poursuite d'Octobre Rouge (1990) comments about writing a memo the next time he gets a bright idea.
Dreamworks Animation's 4th biggest opening for a non-sequel, opening to $50.2 million. It's only behind Home (2015) which opened to $52.1 million, Monsters Vs. Aliens (2009) which opened to $59.3 million, and Kung Fu Panda (2008) which opened to $60.2 million.
Though it proved to be a box office success, grossing nearly $500 million worldwide, it was a critical disappointment. This would be the opposite of Dreamworks Animation's next film, Captain Underpants: The First Epic Movie (2017), which was a critical success but a box office disappointment.
The eighth Dreamworks Animation film to be nominated for the Golden Globe for Best Animated Feature, after Bee Movie (2007), Kung Fu Panda (2008), How to Train Your Dragon (2010), Puss In Boots (2011), Rise of the Guardians (2012), The Croods (2013), and How to Train Your Dragon 2 (2014). Of these, only How to Train Your Dragon 2 has won. Bee Movie lost to Ratatouille (2007), Kung Fu Panda lost to WALL-E (2008), How to Train Your Dragon lost to Toy Story 3 (2010), Puss In Boots lost to The Adventures of Tintin (2011), Rise of the Guardians lost to Brave (2012), and The Croods lost to Frozen (2013). This ended up losing to Coco (2017).
The trivia items below may give away important plot points.
Near the beginning, when the toy steam train is being activated, different toys anticipate the plot. First there is a taxi, in which the baby is delivered; then a police car and fire engine, in which the babies chase Tim; then a barn, referring to the family going to Puppy Co.; then a game of Mouse Trap, in which Tim and Boss Baby get sent to Francis Francis; then an airplane, in which Tim's parents fly; then a pirate ship, referring to Tim and Boss Baby imagining their plane is a pirate ship; then a Habitrail, in which Tim climbs to get to his parents; then a rocket, which is where the Forever Puppies are being launched.
at about 7 minutes) When Tim watches Boss Baby exit the car, Tim is wearing a shirt with the digits '01' imprinted. However, when he gets down the stairs, the digits change to '02'. This indicates his being relegated to second place by Boss Baby.
The scene where Tim and the Boss Baby attempt to steal and replace a file from Puppy Co. is a parody of the famous opening scene from Les aventuriers de l'arche perdue (1981) in which Indiana Jones attempts to steal an idol from a temple.
In the scene where Tim discovers the Boss Baby on the phone to Baby Corp, a Light Brite Toy can be seen in the background depicting a graph with "Babies" going down and "Puppies" going up - a hint of the baby's mission.
The bed Timothy's second daughter is in at the end of the movie says her birthdate is March 31st, 2017; the same day the movie was released. This indicates that the main action of the movie is not based in present day. Further evidence that the movie is not set in the present day is the airplane that Timothy's parents take which appears to be a DC-10 that is no longer used for passenger travel.
When Eugene is dressed up as a nanny-type woman to "take care" of the boys, he resembles Mary Poppins. Then Francis Francis says that she's "practically perfect in every way" which is how Mary Poppins is described in her movie.